Breast Canser


Researchers and clinicians don’t absolutely apprehend why a few cancers unfold and others do no longer. What they do realize is that when most cancers do spread, it dramatically decreases survival fees.

If physicians could predict the probability that the number one tumors will metastasize, they might be capable of pick out the high-quality treatment alternatives for patients. However, contemporary testing most effective evaluations of tumor genetics, that may mutate and change.
Chris Yankaskas, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at Johns Hopkins University, wondered if he should expect metastasis from a one of a kind perspective, by rather searching at the most cancers cellular’s phenotype, or observable mobile traits and behaviors. Under the course of Konstantinos Konstantopoulos, a professor and core college member of the Institute for NanoBioTechnology, Yankaskas and a crew of researchers created the Microfluidic Assay for Quantification of Cell Invasion, or MAqCI, a diagnostic tool and approach for predicting breast cancer metastasis through looking at key cellular behaviors wanted for metastasis in preference to tumor genetics.
“The complexity of most cancers progression and variations among each affected person’s cancer cells make metastasis difficult to predict on a case-through-case basis,” stated Yankaskas. “We intend to preserve operating in breast most cancers using cells from patients’ biopsies and wish to expand the generation to other most cancers types.”

Cancer treatments are strenuous at the body and can be high priced. Some patients need chemotherapy, radiation, surgical operation, targeted cures, or a mixture of all the above. MAqCI can assist clinicians and sufferers perceive the maximum suitable treatment for competitive cancers and keep away from over-treating much less competitive cancers.
To expand their device, Yankaskas first needed to teach MAqCI (suggested mak-see) to recognize the feature behaviors of ordinary breast epithelial cells (their control group), non-aggressive breast most cancers cells, and competitive/metastatic breast most cancers cells. Once those parameters had been set up, the team then used impartial mobile populations, along with with breast most cancers patient-derived specimens, to validate that MAqCI should efficiently measure and symbolize the cells.
The check measures key cell behaviors which might be required for metastasis to occur: cellular motility, the degree of ways capable cells are of journeying to remote websites in the body, and proliferation, that’s how plenty they’re multiplying.

Results, published in Nature Biomedical Engineering, display that MAqCI is accurate, touchy, and unique enough to are expecting if a breast cancer populace will metastasize. The technology has capacity scientific use as it makes use of small pattern sizes, provides results within one to 2 days, and may isolate these cells for similarly characterization.
Another gain of MAqCI testing is that it appears at observable traits of cells and is quite simple and smooth to interpret, unlike genetic screening. Predicting if a most cancers population is able to metastasize can be hard, and this behavioral technique offers an easier, greater powerful way of making a prediction.
“MAqCI has the capacity to diagnose a tumor’s metastatic propensity and screen therapeutics that concentrate on metastasis-initiating cells on an affected person-specific foundation for personalized medication,” Konstantopoulos stated. “We are presently checking out our assay to expect survival expectancy of mind most cancers sufferers. We agree with that MAqCI could be a superb device for analysis, prognosis, and precision care of sufferers with stable tumors.”

New York: Eating soy-wealthy meals can lower the chance of bone fractures in pre-menopausal breast most cancers survivors, shows a brand new look at. The better soy intake was related to seventy-seven in step with cent decreased chance of osteoporotic fractures in younger ladies, the observe confirmed.
In the have a look at, posted in JNCI Cancer Spectrum journal, researchers at Yale University investigated the impact of exercise and soy meals intake on bone fracture charges amongst breast cancer survivors.
“The menopausal transition is known to be a length of high hazard for bone loss, and given the relative shortage of records associated with fracture danger among younger girls with breast cancer, this examine marks a vital contribution to this frame of literature,” stated the paper’s lead creator, Evelyn Hsieh, Assistant Professor at Yale University.
“Our findings, mainly regarding the protective results of soy meals intake, offer novel insight into how future interventions may be excellent tailored to distinct threat groups,” Hsieh said.
For the look at, the crew used statistics from the Shanghai Breast Cancer Survival take a look at five,042 newly recognized breast cancer survivors inside the age institution of 20-75.
The examine discovered soy-based totally foods which are wealthy in isoflavones provide a natural selective estrogen receptor modulator (SERM), which enables in increasing the bone mineral density. Previous research has confirmed the usage of tamoxifen, a SERM or drug, this is prescribed for breast most cancers sufferers reduces the danger of fractures.
Several treatments for breast cancer can reason untimely menopause and decrease bone mineral density, leading to a higher occurrence of osteoporosis-associated fractures among survivors compared with wholesome girls inside the identical age organization.
Breast cancer is the second most commonplace cancer amongst girls in the US, with one in eight ladies diagnosed with it all through their lifetime. If physicians could predict the likelihood that primary tumors will metastasize, they would be able to choose the best treatment options for patients. However, current testing only reviews tumor genetics, which can mutate and change.
Chris Yankaskas, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at Johns Hopkins University, wondered if he could predict metastasis from a different angle, by instead looking at the cancer cell’s phenotype, or observable cell characteristics and behaviors. Under the direction of Konstantinos Konstantopoulos, a professor and core faculty member of the Institute for NanoBioTechnology, Yankaskas and a team of researchers created the Microfluidic Assay for Quantification of Cell Invasion, or MAqCI, a diagnostic tool and method for predicting breast cancer metastasis by looking at two key cell behaviors needed for metastasis instead of tumor genetics.
“The complexity of cancer progression and differences between each patient’s cancer cells make metastasis hard to predict on a case-by-case basis,” said Yankaskas. “We aim to continue working in breast cancer using cells from patients’ biopsies and hope to expand the technology to other cancer types.”Cancer treatments are strenuous on the body and can be costly. Some patients need chemotherapy, radiation, surgery, targeted therapies, or a combination of all of the above. MAqCI can help clinicians and patients identify the most appropriate treatment for aggressive cancers and avoid over-treating less aggressive cancers.

A few days before I become scheduled to go through surgical operation to do away with both of my apparently healthy breasts, I went alone to church, to the seashore, and to my grandmother’s grave. My grandmother died of breast cancer, as did my incredible grandmother. My mother and aunt had battled breast most cancers, too; luckily, they managed to conquer it. Another aunt had just been identified weeks earlier than.
At that factor, I’d been getting ready for my surgery emotionally and bodily for near 5 years. That’s once I first found I carried a BRCA2 gene mutation, which increased my danger of growing breast cancer to as high as eighty-five %. (For non-BRCA mutation companies, the lifetime risk is 12%.) It became 2013 after I first heard of BRCA, and I without delay advised my mother to take the check. It seemed like it may be the lacking hyperlink in the generational chain of women in my own family who had advanced breast cancer.

I do not forget whilst the nurse got here in to inform me that I’d examined the high quality. The first issue out of my mouth was, “I recognize,” because I did. My instinct, coupled with my family records, all but assured me this would be the case.
For a while, I did not inform my mother that I had tested advantageous; I definitely didn’t inform everybody. I wanted to pick out my route of action primarily based by myself gut, now not on the reviews or fears of others. After all, I could be the one who could live with the outcomes for the rest of my existence.
Becoming my own suggest
After I observed out I changed into BRCA fantastic, I decided to research the entirety I may want to approximately it—I even became certified as a holistic most cancers expert. For some time I opted for what doctors name “extended surveillance.” When your private threat is high, the usual guidance (normal mammograms beginning at age forty, in line with most fitness guidelines) doesn’t practice to you. I become slightly in my mid-thirties when I had my first mammogram. In addition to a yearly mammogram, I also had to have a breast MRI, plus two breast ultrasounds and two CA 125 blood checks (to test for a marker it really is related to ovarian most cancers) every 12 months. I commenced performing normal self-assessments, too.
I felt like I changed into being proactive enough, but it becomes onerous to continuously go to the doctor, no longer to mention anxiety-generating. As the years handed, I also knew that my odds have been increasing due to the fact breast cancer risk for everybody is going up with age. At age 30, the average female has a 1 in 227 hazards of being diagnosed with breast cancer within 10 years, however with the aid of age forty, it jumps to at least one in sixty-eight. By age 60, it is 1 in 28.
When I began seeing my breast medical professional, Kristi Funk, MD, she explained that when it comes to hereditary breast most cancers, the most cancers tends to strike earlier and in advance in every next era. That truly appeared to be the case in my own family. My notable-grandmother became in her 70s, my grandma became in her 60s, and my mother becomes forty-nine. Dr. Funk cautioned that I actually have surgical treatment approximately 10 years previous to the age my mother changed into whilst she developed breast cancer. As my thirty-ninth birthday approached, it was time.

A marvel analysis
In the weeks leading as much as my manner, I tossed and became for multiple nights, but my intuition told me that I changed into doing the proper element. Without the surgery, I turned into taking walks around with an 85% chance of developing breast most cancers. In one surgical procedure, I could reduce my threat to beneath 3%. (That’s lower than the hazard for the general populace.)
When I became wheeled into surgical operation in October 2018, I felt assured and empowered. I awoke to feel groggy but relieved that it becomes all at the back of me. I had no idea that the most surprising part turned into but to come.
Six days after my surgical treatment, whilst I turned into nonetheless bandaged up and had drains popping out of my sides, I obtained a sudden call from my health practitioner. She said the final aspect I predicted to pay attention: I had breast cancer.

My mind becomes completely blown. Apparently, it’s the general process to run tests on the breast tissue it really is been removed during a mastectomy—even if the procedure is prophylactic. My medical doctor explained that my checks had come back showing that I had stage zero non-invasive breast most cancers, also called DCIS, for ductal carcinoma in situ.
The National Cancer Institute now refers to degree 0 breast most cancers as a “noninvasive circumstance,” since the cells haven’t unfolded past the lining of the breast ducts. In the six months leading up to my procedure, I had had a mammogram, a breast ultrasound, and a breast MRI, and they had all come returned clear.
Because the cancer became at such an early degree, the most effective way to discover it is through preventive surgical treatment. And because I’d already had the surgical treatment and the cancerous tissue was eliminated, I might no longer want to do any extra remedy—no chemo, no radiation, no hormonal treatment important. I in no way idea I’d have my selection confirmed like that. Turns out, I beat cancer before I knew I had it.

Are you a betting man? Your odds of having most cancers are higher than you observed.
In reality, in step with a examine in the British Journal of Cancer, 54% of guys born considering 1960 will finally expand cancer. This wide variety has been rising, in part because we’re residing longer but additionally because of obesity and positive lifestyle selections associated with it. The threat for men of all ages is 40 percentage, consistent with the American Cancer Society.
Two cancers honestly pop to mind: prostate—the most normally recognized cancer in guys—and lung, which debts for the maximum deaths. But men get breast cancer too. And if the ailment runs to your family, your hazard is kind of similar to it is for women.
Here are eight things guys need to recognize (but probably don’t).

If you’re to your 40s, you may want to keep in mind switching from digital mammography to virtual breast tomosynthesis (DBT) to your next breast cancer screening, say the authors of a examine published online February 28 with the aid of JAMA Oncology.
An evaluation of more than a hundred and seventy,000 screening mammograms the usage of the 2 technologies decided that DBT — every so often referred to as 3D mammography — did a better activity at appropriately detecting cancers in girls of every age. The benefits had been maximum suggested for girls of their 40s. DBT became additionally higher at locating cancers in girls with high breast density, that may make cancers tougher to identify on screening tests. High density suggests a bigger share of active tissue inside the breast and is a danger component for breast cancer.
“This study contributes to what’s already an honest amount of proof that suggests, especially for more youthful women and girls who’ve denser breasts, that DBT might be a better screening take a look at,” says Dr. Jennifer Haas, one of the look at’s authors and a professor of medication at Harvard Medical School.
A new technology
DBT is a quite new technology, approved with the aid of the FDA in 2011. It works by way of taking a series of pix, which a computer then assembles right into a 3-D-like photograph of breast slices. Traditional virtual mammography creates a -dimensional image of a flattened breast, and the radiologist should peer thru the layers to find abnormalities.
The have a look at authors in comparison the two technologies the use of greater than 50,000 breast screenings carried out with DBT and 129,369 done with virtual mammography. The records represented more than ninety-six,000 ladies (average age fifty-four to fifty-six) screened at three specific research facilities from 2011 to 2014.
The look at’s strengths are the huge pattern length and how it was designed to degree the experience of ladies in actual medical practice, says Dr. Haas.
“In contrast to participants in a medical trial, this study tested the results of ladies receiving care in a ramification of medical practices. It represents a set of girls who’re regular of people who get annual mammographic screenings,” she says.
The findings
Study authors observed that DBT produced higher cancer detection charges and fewer needless callbacks in girls of every age. But the generation achieved mainly nicely on women of their 40s. In this institution, DBT discovered 1.7 extra cancers than virtual mammography for every 1,000 tests of girls with everyday breast tissue. In addition, 16.3% of ladies in this age group who had been screened using virtual mammography obtained callbacks, as opposed to 11.7% of these screened using DBT. For younger women with dense breasts, the advantage of DBT was even extra: 2.27 greater cancers have been observed for every 1,000 girls screened.
Women with high breast density have long represented an undertaking for radiologists. Dense tissue and cancers each show up as white regions on screening mammograms, making it difficult for the radiologist reading the exam to distinguish among regular and strange tissue. Some radiologists have defined searching out most cancers on these snapshots as attempting to find a polar bear in a snowfall.

A new most cancers look at made headlines this week as researchers found that a low-fat weight-reduction plan allows reducing the threat of loss of life from breast most cancers. The findings of this huge, long-time period have a look at could have lifestyles converting consequences for hundreds of thousands of girls.

Tali Lando, a pediatric ear, nostril, and throat health care provider, changed into recognized with complicated breast cancer 5 years in the past, whilst she was 37-years-antique.
“The fact for me changed,” she instructed CBS News. “I am nevertheless here these days so that is the coolest news.”

After the surgical procedure, chemotherapy, and radiation, Lando completely modified her weight-reduction plan. New facts suggest that the impact of this selection is real. Women who followed a balanced, low-fat diet had a 21% decrease chance of death from breast most cancers, and a 15% decrease danger from dying from any motive compared to women, not on a low-fat weight loss plan, consistent with the American Society of Clinical Oncology.
“You have to lower your fat intake if you actively need to be undoubtedly affecting your survival from this sickness. It’s almost like a license to present a prescription now to peer a nutritionist and trade your eating regimen,” said Dr. Manasseh, leader of breast surgical treatment at Maimonides Medical Center.
The 20-12 months study accompanied forty-eight,835 submit-menopausal girls who did now not have breast cancer after they enrolled. One organization adopted a lower fats food regimen with day by day servings of fruit, greens, and grains and reduce fats consumption to approximately 25% of overall calories. The control organization endured their normal eating regimen, with fat accounting for approximately a 3rd of overall calories, 32%, in accordance with the American Society of Clinical Oncology.
“These without a doubt are not difficult things to do. I assume the issue is available in what the supply is of those items within the residence or inside the domestic,” Dr. Manasseh stated.
“You can’t trade your genetics and also you can not change the truth of the tumor you had been identified with, but you could most effective control positive things, and that is a huge one … Eating regimen,” Lando stated.
The look at shows that dietary adjustments do not need to be drastic to have a lasting effect.

DALLAS–(BUSINESS WIRE)–Today, Susan G. Komen®, the sector’s main breast most cancers employer, announced the release of a new podcast, Real PinkTM, debuting on Apple Podcasts, Google Play, Spotify, Stitcher, and all different podcast platforms this month. The Real Pink podcast is a weekly series that brings humans collectively for significant and honest conversations approximately breast cancer – tackling difficult, emotional or existence-converting issues and subjects.

Each week, host Adam Walker will interview people who’ve been impacted by using breast most cancers, or those on the front traces in the combat against the disorder, along with celebrities, survivors, humans residing with the ailment, physicians, researchers and advocates to offer their private perspectives and primary-hand statistics and steering. Through Real Pink, Susan G. Komen will attempt to help those affected by breast cancer – inclusive of sufferers and the people in their lives who love them – by means of providing the facts needed to make informed decisions.
“We realize that a breast cancer diagnosis affects every single thing of lifestyles, inclusive of relationships, finances, jobs and the entirety in among,” says Linda Fisk, senior vice chairman, marketing at Susan G. Komen. “It is our desire that the uncooked discussions on Real Pink are simply the begin of continued conversations with friends, family, medical doctors, nurses and others relied on participants of their team.”

. Our delegation — UNICEF USA staff, our Regional Board contributors and Zontians from around the arena — are invited to bop with the network. After introductions with nearby leaders, we’re ready to fulfill the Mother Leaders.
More than a dozen moms across a wide age variety lead us toward the shore, making a song joyously alongside the way. At their meeting place, we are advocated to clean our arms with ash (given that cleaning soap isn’t broadly to be had), and they invite us into the circle. What we see subsequent is Communications for Development (C4D) in motion; at the coronary heart of every tune is a lesson, ranging from menstrual hygiene to treating water to spacing out pregnancies.

Families have accumulated around to observe and the keenness is palpable. “Songs are crucial because they assist us to be more dynamic so that we feel at ease and won’t neglect what we’re presupposed to do,” says Zeme, 22, a Mother Leader with three children of her own. She says she’s found out a lot within the function: “I become advocated by using my education and in turn, I can encourage the [other] moms. I can share what I recognize approximately hygiene with [them].”

One of the key messages that Mother Leaders like Zeme pressure domestic are the importance of education. “We encourage moms to send their youngsters to school considering that those kids can assist them once their schooling is finished,” she says. But among school fees and other simple necessities like meals and garments, how are families able to make ends meet?
That’s in which the opposite key obligation of the Mother Leaders is available in. With an assist from Let Us Learn, families in the network acquire cash transfers that may be used to buy food, medicinal drug, and water elements, freeing up income that may be used to sign up children in faculty. The quantity is small at about $3.40 according to a child every two months, however, the effect is lifestyles-changing. “Before, we had no peace at domestic. We didn’t have plenty for living,” says Zeme. “We used to have grimy, torn garments. Once we knew about [the cash transfer program], our high-quality of existence progressed significantly.”

Each Mother Leader is accountable for education up to 25 different ladies who also enjoy the program. “I educate them how to manipulate their cash so we can take care of it wisely and stay in exact fitness,” says Zeme. For mothers who’ve confronted desperate instances for goodbye, the coins transfers are releasing, permitting them to give their youngsters a way of breaking the cycle of poverty. “Our children are very glad because they have notebooks, pens, and uniforms. They are eager to move to high school and feature desire for the destiny.”
In Madagascar, one of the poorest international locations within the world, every day demanding situations can frequently sense daunting, but as we wrap up this go to, it is tough not to sense hopefully for the destiny of this network. With UNICEF’s assist, the Mother Leaders have taken this software and made it their own, growing a version it really is sustainable and empowering. As we are saying good-bye, Zeme shares one last wish: “That my children might emerge as instructors or scientific medical doctors. It might be an honor.” That has never felt extra feasible.

In addition to being a co-founder of the AiRS Foundation and clear skin care line, Janet Denlinger, Ph.D. is also the president of Matrix Biology Institute, a non-earnings medical research business enterprise intended to promote studies on hyaluronic acid.
From early adolescence, Denlinger had an interest in biology and physiology. After incomes a degree in endocrinology at Purdue, she worked in pharmacology, body structure, and biochemistry. She came to Columbia University Medical School in 1975, then worked in France, wherein she finished a Ph.D. at the Université des Sciences et Techniques in Lille.
The greatest demanding situations Denlinger confronted in her profession related to the roles of men vs. Women in the Nineteen Sixties. “We have come to a protracted manner, but ladies nevertheless have much to show to others in addition to ourselves,” she says. “I experience very strongly about the significance of mentoring.” The best reward she has experienced is understanding that she constantly had selections thanks to her hard work, core values, and commitment to doing nicely.
Volunteerism always has been a huge part of Denlinger’s life. “When one does properly, one has to desire to make contributions to the good of society and, specifically, others,” she says. This is what stimulated her to cofound AiRS with Hare.
To aspiring changemakers, Denlinger says, “Know who you are and what you need to do, then pursue your goals with all your strength. Investigate and ask questions. Take gain of every learning possibility. Talk to folks who are in your selected profession. Seek out, mentors.”
MeiMei Fox is a New York Times bestselling writer that specializes in health, wellbeing and high-quality psychology. As an author and life educate, she allows humans to align careers with their lifestyles reason.
In Tanandava, a small community in Madagascar’s Anosy place, the ravages of climate trade and drought are felt mainly difficult. Food lack of confidence is a regular for many. Opportunities for youngsters are frequently few and ways among. And yet, with help from UNICEF and companions like Zonta International, a small but resilient group of moms are lifting up their community and enhancing existence notably.
Getting to this far off the lakeside city isn’t clean. As with most regions in Madagascar’s south, the few paved roads haven’t been repaired in many years. Though UNICEF’s rugged SUVs are as much as the mission, it’s tough to imagine most vehicles being able to traverse the frequently rocky terrain. As we get closer to Tanandava, we see sand dunes within the distance — a picturesque sight, but also a reminder of the creeping desertification here.
We had spent plenty of that week touring school rooms and gazing instructions, all of which had been prepared via Let Us Learn, a UNICEF initiative supported with the aid of Zonta and different donors that specializes in reaching out-of-faculty youngsters, in particular women, with pleasant schooling programs. There’s a real education crisis in Madagascar: handiest one out of every three kids completes primary faculty. We’re reminded of this as we see youngsters sitting with the aid of the welcome sign up the outskirts of the Metropolis.

Up to 70% of breast, most cancers survivors who have had mastectomies are uncertain or unaware of their reconstruction alternatives. The Alliance in Reconstructive Surgery (AiRS) Foundation is a non-profit business enterprise devoted to raising attention and finances for ladies who’ve had mastectomies and cannot have enough money reconstructive surgical operation. It changed into founded in 2012 by means of Janet Denlinger, Morgan Hare, and Dr. Rod Rohrich, who experience that while every woman might not need reconstructive surgery, all of them have to have a choice, regardless of their monetary state of affairs. To date, the muse has helped over a hundred women. A winner of the Saks Fifth Avenue Key for the Cure initiative in 2018, AiRS plans to double that wide variety inside the subsequent year.

The biggest challenge faced with AiRS are financing, and additionally reaching ladies who need to be knowledgeable about their reconstruction options and need economic help but don’t recognize that the non-profit exists. The foundation is running tough to reach out to these ladies through a selection of strategies, which include establishing relationships with different businesses within the space inclusive of Susan G. Komen, The American Cancer Society, Hospital Navigators, and the Patient Advocate Foundation.
AiRS cofounder Morgan Hare majored in technology and worked in lab studies prior to coming across her passion for marketing. She has held executive marketing, product development, and digital retailing positions in pores and skin care at several countrywide client product groups, which includes Revlon, Avon, QVC, Home Shopping Network, Tupperware, and BeautiControl. With her pricey pal of 44 years, Janet Denlinger, Hare launched Heraclea skin care line in 2011, for which she serves as president.
Hare has faced demanding situations as a lady inside the place of job. “There have been instances in my career while men felt they have to have been promoted over me, despite the fact that I changed into accomplishing my desires and they weren’t. Similarly, I have dealt with ladies who are threatened through other girls in the place of work. We need to assist every different, not hinder our mutual progress,” she says.
Growing up, Hare always knew that she wanted to provide again. As she advanced in her career, she made a promise to herself that she might help other women reap their dreams and sense true about themselves. And so, after founding Heraclea, Hare and Denlinger teamed up with Dr. Rod Rohrich, a founding professor and chair of the Department of Plastic Surgery at UT Southwestern Medical Center, to shape the AiRS Foundation.“For many women, reconstruction is a crucial part of the healing method and a massive a part of feeling healed,” says Hare. “ It restores shallowness and wholeness after breast cancer surgery. Even although Janet and I, like everybody else, have had our percentage of united states and downs, we sense blessed and need to offer a voice to a cause that has none.”
Hare says she is satisfied with the selections and accomplishments she has made in lifestyles. “Everything I have done, each process I even have had, has given me enjoy that I become capable of applying not only to being part of a successful entrepreneurial business enterprise but additionally to the relaxation of my life.” To aspiring changemakers, she says, “The only matters which can restrict us are the boundaries we put on ourselves.”

Twitter is notable for plenty of things. Diagnosing breast cancer is not certainly one of them.
Since the first National Breast Cancer Awareness Month in October 1985, millions of girls (and plenty of men too) have been influenced to take action inside the shape of a probably existence-saving mammogram—37 million are executed each year. Which is tremendous.
Problem is, awareness can also breed fiction, and our social feeds and email inboxes are in particular adept at spreading medical facts that aren’t exactly correct. Or even remotely accurate.
Here are 10 common breast cancer myths you want to stop believing, like, nowadays.

NEW YORK (GenomeWeb) – Agendia stated these days that it has signed an agreement with Valencia, Spain-based Imogen for the specific distribution of Agendia’s MammaPrint and BluePrint breast most cancers genomic assessments in Spain and Portugal.
MammaPrint measures the expression of 70 genes and classifies sufferers as either excessive threat or low hazard of recurrence over a 10-yr period. BluePrint is an eighty-gene assay that classifies sufferers as having both basal, luminal, or HER2 subtypes of breast most cancers to further manual treatments.
Both assessments are primarily based on microarray era. Agendia additionally one at a time markets the MammaPrint and BluePrint Breast Cancer Recurrence and Molecular Subtyping Kits the use of subsequent-era RNA sequencing era.
“We are very thrilled to have Imogen as a companion within the distribution of MammaPrint and BluePrint due to their information inside the vicinity of oncological genomics and experience in the Spanish market,” Agendia CEO Mark Straley said in a statement. “Together, we will bring our testing knowledge to the nearly 25,000 ladies annually identified with breast most cancers on the Iberian Peninsula.”Up to 70% of breast cancer survivors who have had mastectomies are unsure or unaware of their reconstruction options. The Alliance in Reconstructive Surgery (AiRS) Foundation is a non-profit organization dedicated to raising awareness and funds for women who have had mastectomies and cannot afford reconstructive surgery. It was founded in 2012 by Janet Denlinger, Morgan Hare, and Dr. Rod Rohrich, who feel that while every woman might not want reconstructive surgery, they all should have a choice, regardless of their economic situation. To date, the foundation has helped over 100 women. A winner of the Saks Fifth Avenue Key for the Cure initiative in 2018, AiRS plans to double that number in the next year. The biggest challenge faced with AiRS are financing, and also reaching women who want to be educated about their reconstruction options and need financial help but don’t know that the non-profit exists. The foundation is working hard to reach out to these women through a variety of methods, including establishing relationships with other organizations in the space such as Susan G. Komen, The American Cancer Society, Hospital Navigators, and the Patient Advocate Foundation.
AiRS cofounder Morgan Hare majored in science and worked in lab research prior to discovering her passion for marketing. She has held executive marketing, product development, and electronic retailing positions in skin care at several national consumer product companies, including Revlon, Avon, QVC, Home Shopping Network, Tupperware, and BeautiControl. With her dear friend of 44 years, Janet Denlinger, Hare launched Heraclea skincare line in 2011, for which she serves as president.

Months after the FDA sanctioned the approval of Roche’s runner up checkpoint inhibitor Tecentriq in mixture with Celgene’s Abraxane for treatment-naive patients with triple negative breast cancer, Merck’s keynote PD-1 Keytruda has stumbled in a late-stage trial as the second one or 1/3 line of defense towards the rare, competitive form of most cancers.
Patients within the 622-patient trial have been both given the blockbuster treatment or chemotherapy. The main aim of the examine — normal survival — was no longer met, Merck stated, including that information can be disclosed at a later date.
The US drugmaker will retain to check Keytruda monotherapy and in aggregate with chemotherapy in advance tiers of the hard-to-deal-with the disorder.
About 10-20% of all breast cancers are triple-poor breast cancers (TNBCs), which ordinarily has an excessive recurrence charge within the first five years after diagnosis. In TNBC patients, the increase of the most cancers isn’t fueled via the hormones estrogen and progesterone, or by way of the HER2 protein, making it hard to treat.
Roche’s Tecentriq aggregate with Abraxane was the primary-ever immunotherapy to get approval within the first line TNBC placing. The approval becomes key for the Swiss drugmaker this is third-in-line — in the back of Bristol-Myers Squibb and Merck — for the checkpoint inhibitor Iron Throne. The massive drugmaker should get beforehand of its rivals in vital most cancers areas if it wants to keep on to its position, as AstraZeneca carves out a gap for its PD-L1 checkpoint Imfinzi in a subset of non-small cell lung cancer sufferers.
About 70% of breast cancers identified in human beings with an inherited BRCA mutation, specifically BRCA1, are identified with TNBC. PARP inhibitors such as AstraZeneca’s Lynparza and Pfizer’s Talzenna are already permitted for germline BRCA-mutated breast most cancers and are being investigated in aggregate with checkpoint inhibitors for TNBC.
Meanwhile, antibody-drug conjugates are any other capability remedy choice for TNBC underneath research. Twitter is great for a lot of things. Diagnosing breast cancer is not one of them.
Since the first National Breast Cancer Awareness Month in October 1985, millions of women (and many men too) have been motivated to take action in the form of a potentially life-saving mammogram—37 million are done each year. Which is fantastic.
Problem is, awareness can also breed fiction, and our social feeds and email inboxes are especially adept at spreading medical information that isn’t exactly correct. Or even remotely correct.
Here are 10 common breast cancer myths you need to stop believing, like, today.

NEW YORK (GenomeWeb) – Agendia said today that it has signed an agreement with Valencia, Spain-based Imogen for the exclusive distribution of Agendia’s MammaPrint and BluePrint breast cancer genomic tests in Spain and Portugal.
MammaPrint measures the expression of 70 genes and classifies patients as either high risk or low risk of recurrence over a 10-year period. BluePrint is an 80-gene assay that classifies patients as having either basal, luminal or HER2 subtypes of breast cancer to further guide treatments.
Both tests are based on microarray technology. Agendia also separately markets the MammaPrint and BluePrint Breast Cancer Recurrence and Molecular Subtyping Kits using next-generation RNA sequencing technology.
“We are very pleased to have Imogen as a partner in the distribution of MammaPrint and BluePrint because of their knowledge in the area of oncological genomics and experience in the Spanish market,” Agendia CEO Mark Straley said in a statement. “Together, we will bring our testing expertise to the nearly 25,000 women annually diagnosed with breast cancer on the Iberian Peninsula.”